Scientists From the research center of the hospitals of the Montreal Institute (CRCHUM) have recommended, in fact, that immunotherapeutic healing in front of cancer has the ability to reduce the number of microbes, which is saved in humans on triple therapy. In a study published in the journal Nature Communications, they demonstrate, in the cells of people living with HIV, how these ways of healing open up a virus—still hidden in the hollows of infected cells—to the immune system.

"We have identified a device with the support of which antitumor immunotherapy "awakens" the microbe from the shelters and reduces the size of HIV reservoirs in people receiving triple therapy. But the bulk of our experiments were conducted in vitro, our alignment has the ability to lead to the development of fresh treatments," said Nicholas Chaumont, a researcher at CRCHUM and a doctor at the Montreal Institute.

HIV reservoirs are cells and tissues, in which the microbe is saved, not paying attention to triple therapy. This healing predosteregaet the establishment of infection in the acquired immunodeficiency syndrome (AIDS). In order to endure all the hardships and multiply, HIV must be located in the cell. As a rule, it infects CD4+ T-lymphocytes, snow-white blood cells that are responsible for activating the body's defense against infection.

The microbe remains dormant in these cells and makes a reservoir that is controlled but not eliminated by antiretroviral products. The subject of enhanced research, these reservoir cells are considered the last obstacle to microbial eradication and force people living with HIV to take on antiretroviral drugs for the rest of their lives.

In 2016, Remy Fromentin, a researcher at the laboratory of Nicolas Chaumont, recommended that the cells, in which there are resistant microbes, possess specific immunological features: 3 proteins, called PD-1, LAG-3 and TIGIT, which are often expressed on their plane. Now these molecules are considered to be the target of immunotherapy used to cure cancer. Scientists have decided to assess the impact of these methods of healing on the reservoirs of HIV.

A strategy evaluated in a small number of people with HIV and cancer

"Our results prove that immunotherapy aimed at molecules, such as PD-1, has the ability to reduce the number of microbes remaining in humans on triple therapy. One of the appropriate steps will be the intricacies of immunotherapy with molecules that have so far been ineffective in eradicating HIV reservoirs. This intricacy of immunotherapy and chemical molecules has the ability to" Wake up" the microbe and help to send cells infected with HIV", - said Chaumont.

In this note, Remy Fromanten and Nicolas Chaumont still suggest data from a patient from Montreal infected with HIV and received immunotherapy melanoma.

"The magnitude of the HIV reservoirs, it is important the patient declined, in fact that encouraging. However, we must be careful, due to the fact that it does not work with all patients. These treatments still interfere with important side effects, " Fromentin shown. The results of real-time clinical testing in the United States for cancer and HIV patients are required to assist in future studies.

Almost 37 million people worldwide are living with HIV. Any day, 5000 cases, as it is told, mass health authorities.