Like almost all other honey diseases, the device of confused sclerosis remains a mystery-a mystery consisting of difficult genetic and environmental moments. The main part of this puzzle is considered to be the immune system, which is still responsible for the adjustment of many other physical (and pathological) phenomena, covering allergies. But past studies studying the Association between MS and allergies, have given mixed results, the research team at the Brigham and women's clinic tried to uncover the acceptable Association over. Exploring the link between allergies and vigor of the inflammatory disease, the team noticed a fresh confirmation, linking food Allergy and recurrence of a confused sclerosis. The results are published in the journal of neurology, neurosurgery and psychiatry.

"Some patients with multiple sclerosis with a significant Allergy would complain of frequent relapses associated with their allergic episodes," said Tanya Chitnis, a medical doctor, senior Creator and neurologist at the MS Partners center in Brigham. “We thought that the more possible device associated with allergies and its effects on MS would be associated with inflammatory energy.”

In line with this, Chitnis and a co-worker intended to study the Association between the vigor of inflammatory diseases and the Allergy situation in a subset of patients included in a tremendous study, familiar as an all-encompassing longitudinal study of confused sclerosis in Brigham and the ladies ' clinic (CLIMB). Common challenges in 1349 the members of the Autonomous learning has filled the questionnaire with the description of food, environmental and/or pharmaceutical allergies. The energy of the disease was perceived by the assessment of the continuous number of attacks per course of the disease, and fresh gadolinium (gir)-the expansion of foci detected on MRI.

Curiously, the fact that only group members food allergies revealed important more sublime degree of common attacks and increases the possibility of fresh reptile-lesions, in comparison with members with food allergies. This influence remained important even when adjusted for likely confounders as gender, age on the pressure characteristic, and the category of disease. Subsequently, no significant effects for environmental and pharmaceutical Allergy groups were observed in the adjusted analyses.

This Association between food Allergy and energy of MS disease focuses on the significant role of the probable player in immunity and inflammation–the intestine. "It is interesting, in fact, that this connection was revealed only with the ball food Allergy, and not with other forms of Allergy, which could be expected, if it was the task of immune rejection," - said Chitnis. "The presence of food Allergy and devices associated with food Allergy has the ability to increase the frequency of relapses and inflammatory energy in painful MS. It has the ability to be an artel device here, or other mechanisms that have all the chances to induce relapses of MS in a predisposed owner.”

In real time, Chitnis and colleague work further for this in order to uncover these mechanisms of immune dysregulation in allergies and qualify as this dysregulation densely compresses the work with MS inflammatory. Taking into account the relative nature of this study, scientists will try to highlight the limited clinical efficacy of their own conclusions. What is not the least, Chitnis is optimistic about the likely translational significance of the work and emphasizes the importance of the conclusion of food allergies in the care of patients with MS.

"For a long time there is a guess that the intestinal tract is connected with the immune system, and it really shows a stronger Association than previously understood," said Chitnis. “This study reveals a fresh method of thinking about immune mechanisms in MS.”